The horse originally evolved to be bay and dun in colour. Prezwalski's horse is typical of what the ancestors of the modern horse looked like (colour wise at least) before nature in the form of mutations at cellular level, and humans by selective breeding, created and multiplied a whole range of new colours. The genes responsible for controlling black and red pigment production are extension and agouti. The primitive or wild type version of both genes is denoted by E and A respectively. And this is how they work.... Skin cells in the horse produce red pigment by default – true story! Black pigment production is only switched on when special protein molecules located in the outer membranes of the melanocytes (melanocytes are the skin cells that produce pigment in the skin and coat) receive a signal to do so from a hormone called alpha-melanocyte-stimulating hormone (a-MSH). These protein molecules are called melanocortin 1 receptor protein (MC1R) mole...
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